| Date | Home | Away | Result |
|---|---|---|---|
| 28/10/25 17:30 | Eintracht Frankfurt | Borussia Dortmund | 3-5a.PSO |
| 28/10/25 17:30 | VfL Wolfsburg | Holstein Kiel | 0-1 |
| 28/10/25 17:30 | Hertha BSC | SV Elversberg | 3-0 |
| 28/10/25 17:30 | 1. FC Heidenheim 1846 | Hamburger SV | 0-1 |
| 28/10/25 19:45 | FC St. Pauli | 1899 Hoffenheim | 10-9a.PSO |
| 28/10/25 19:45 | FC Augsburg | VfL Bochum | 0-1 |
| 28/10/25 19:45 | Energie Cottbus | RB Leipzig | 1-4 |
| 28/10/25 19:45 | Bor. Mönchengladbach | Karlsruher SC | 3-1 |
| 29/10/25 17:00 | SpVgg Greuther Fürth | 1. FC Kaiserslautern | --- |
| 29/10/25 17:00 | FSV Mainz 05 | VfB Stuttgart | --- |
| 29/10/25 17:00 | SC Paderborn 07 | Bayer 04 Leverkusen | --- |
| 29/10/25 17:00 | FV Illertissen | 1. FC Magdeburg | --- |
| 29/10/25 19:45 | 1. FC Köln | FC Bayern Munich | --- |
| 29/10/25 19:45 | SV Darmstadt 98 | FC Schalke 04 | --- |
| 29/10/25 19:45 | Fortuna Düsseldorf | SC Freiburg | --- |
| 29/10/25 19:45 | 1. FC Union Berlin | Arminia Bielefeld | --- |